A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.
Identifieur interne : 001042 ( Main/Exploration ); précédent : 001041; suivant : 001043A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.
Auteurs : G. Spyrou [Suède] ; W. Wilson ; C A Padilla ; A. Holmgren ; A. Miranda-VizueteSource :
- Human genetics [ 0340-6717 ] ; 2001.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Alignement de séquences (MeSH), Animaux (MeSH), Cartographie physique de chromosome (MeSH), Chromosomes humains (génétique), Glutarédoxines (MeSH), Génome humain (MeSH), Humains (MeSH), Oxidoreductases (MeSH), Phylogenèse (MeSH), Protéines (génétique), Pseudogènes (génétique), Similitude de séquences d'acides nucléiques (MeSH), Séquence nucléotidique (MeSH), Thiorédoxines (génétique).
- MESH :
- génétique : ARN messager, Chromosomes humains, Protéines, Pseudogènes, Thiorédoxines.
- métabolisme : ARN messager.
- Alignement de séquences, Animaux, Cartographie physique de chromosome, Glutarédoxines, Génome humain, Humains, Oxidoreductases, Phylogenèse, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
English descriptors
- KwdEn :
- Animals (MeSH), Base Sequence (MeSH), Chromosomes, Human (genetics), Genome, Human (MeSH), Glutaredoxins (MeSH), Humans (MeSH), Oxidoreductases (MeSH), Phylogeny (MeSH), Physical Chromosome Mapping (MeSH), Proteins (genetics), Pseudogenes (genetics), RNA, Messenger (genetics), RNA, Messenger (metabolism), Sequence Alignment (MeSH), Sequence Homology, Nucleic Acid (MeSH), Thioredoxins (genetics).
- MESH :
- chemical , genetics : Proteins, RNA, Messenger, Thioredoxins.
- chemical , metabolism : RNA, Messenger.
- chemical : Glutaredoxins, Oxidoreductases.
- genetics : Chromosomes, Human, Pseudogenes.
- Animals, Base Sequence, Genome, Human, Humans, Phylogeny, Physical Chromosome Mapping, Sequence Alignment, Sequence Homology, Nucleic Acid.
Abstract
The thioredoxin/glutaredoxin family consists of small heat-stable proteins that have a highly conserved CXXC active site and that participate in the regulation of many redox reactions. We have searched the human genome sequence to find putative pseudogenes (non-functional copies of protein-coding genes) for all known members of this family. This survey has resulted in the identification of seven processed pseudogenes for human Trx1 and two more for human Grx1. No evidence for the presence of processed pseudogenes has been found for the remaining members of this family. In addition, we have been unable to detect any non-processed pseudogenes derived from any member of the family in the human genome. The seven thioredoxin pseudogenes can be divided into two groups: Trx1-psi2, -psi3, -psi4, -psi5 and -psi6 arose from the functional ancestor, whereas Trx1-psi1 and -psi7 originated from Trx1-psi2 and -psi6, respectively. In all cases, the pseudogenes originated after the human/rodent radiation as shown by phylogenetic analysis. This is also the case for Grx1-psi1 and Grx1-psi2, which are placed between rodent and human sequences in the phylogenetic tree. Our study provides a molecular record of the recent evolution of these two genes in the hominid lineage.
DOI: 10.1007/s004390100597
PubMed: 11702225
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.</title><author><name sortKey="Spyrou, G" sort="Spyrou, G" uniqKey="Spyrou G" first="G" last="Spyrou">G. Spyrou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institute, 141 57 Huddinge, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institute, 141 57 Huddinge</wicri:regionArea><wicri:noRegion>141 57 Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, W" sort="Wilson, W" uniqKey="Wilson W" first="W" last="Wilson">W. Wilson</name></author><author><name sortKey="Padilla, C A" sort="Padilla, C A" uniqKey="Padilla C" first="C A" last="Padilla">C A Padilla</name></author><author><name sortKey="Holmgren, A" sort="Holmgren, A" uniqKey="Holmgren A" first="A" last="Holmgren">A. Holmgren</name></author><author><name sortKey="Miranda Vizuete, A" sort="Miranda Vizuete, A" uniqKey="Miranda Vizuete A" first="A" last="Miranda-Vizuete">A. Miranda-Vizuete</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11702225</idno><idno type="pmid">11702225</idno><idno type="doi">10.1007/s004390100597</idno><idno type="wicri:Area/Main/Corpus">001013</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001013</idno><idno type="wicri:Area/Main/Curation">001013</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001013</idno><idno type="wicri:Area/Main/Exploration">001013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.</title><author><name sortKey="Spyrou, G" sort="Spyrou, G" uniqKey="Spyrou G" first="G" last="Spyrou">G. Spyrou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institute, 141 57 Huddinge, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institute, 141 57 Huddinge</wicri:regionArea><wicri:noRegion>141 57 Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, W" sort="Wilson, W" uniqKey="Wilson W" first="W" last="Wilson">W. Wilson</name></author><author><name sortKey="Padilla, C A" sort="Padilla, C A" uniqKey="Padilla C" first="C A" last="Padilla">C A Padilla</name></author><author><name sortKey="Holmgren, A" sort="Holmgren, A" uniqKey="Holmgren A" first="A" last="Holmgren">A. Holmgren</name></author><author><name sortKey="Miranda Vizuete, A" sort="Miranda Vizuete, A" uniqKey="Miranda Vizuete A" first="A" last="Miranda-Vizuete">A. Miranda-Vizuete</name></author></analytic><series><title level="j">Human genetics</title><idno type="ISSN">0340-6717</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Base Sequence (MeSH)</term><term>Chromosomes, Human (genetics)</term><term>Genome, Human (MeSH)</term><term>Glutaredoxins (MeSH)</term><term>Humans (MeSH)</term><term>Oxidoreductases (MeSH)</term><term>Phylogeny (MeSH)</term><term>Physical Chromosome Mapping (MeSH)</term><term>Proteins (genetics)</term><term>Pseudogenes (genetics)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Sequence Alignment (MeSH)</term><term>Sequence Homology, Nucleic Acid (MeSH)</term><term>Thioredoxins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Alignement de séquences (MeSH)</term><term>Animaux (MeSH)</term><term>Cartographie physique de chromosome (MeSH)</term><term>Chromosomes humains (génétique)</term><term>Glutarédoxines (MeSH)</term><term>Génome humain (MeSH)</term><term>Humains (MeSH)</term><term>Oxidoreductases (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Protéines (génétique)</term><term>Pseudogènes (génétique)</term><term>Similitude de séquences d'acides nucléiques (MeSH)</term><term>Séquence nucléotidique (MeSH)</term><term>Thiorédoxines (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteins</term><term>RNA, Messenger</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Glutaredoxins</term><term>Oxidoreductases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human</term><term>Pseudogenes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Chromosomes humains</term><term>Protéines</term><term>Pseudogènes</term><term>Thiorédoxines</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Genome, Human</term><term>Humans</term><term>Phylogeny</term><term>Physical Chromosome Mapping</term><term>Sequence Alignment</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Cartographie physique de chromosome</term><term>Glutarédoxines</term><term>Génome humain</term><term>Humains</term><term>Oxidoreductases</term><term>Phylogenèse</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The thioredoxin/glutaredoxin family consists of small heat-stable proteins that have a highly conserved CXXC active site and that participate in the regulation of many redox reactions. We have searched the human genome sequence to find putative pseudogenes (non-functional copies of protein-coding genes) for all known members of this family. This survey has resulted in the identification of seven processed pseudogenes for human Trx1 and two more for human Grx1. No evidence for the presence of processed pseudogenes has been found for the remaining members of this family. In addition, we have been unable to detect any non-processed pseudogenes derived from any member of the family in the human genome. The seven thioredoxin pseudogenes can be divided into two groups: Trx1-psi2, -psi3, -psi4, -psi5 and -psi6 arose from the functional ancestor, whereas Trx1-psi1 and -psi7 originated from Trx1-psi2 and -psi6, respectively. In all cases, the pseudogenes originated after the human/rodent radiation as shown by phylogenetic analysis. This is also the case for Grx1-psi1 and Grx1-psi2, which are placed between rodent and human sequences in the phylogenetic tree. Our study provides a molecular record of the recent evolution of these two genes in the hominid lineage.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11702225</PMID><DateCompleted><Year>2001</Year><Month>12</Month><Day>07</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-6717</ISSN><JournalIssue CitedMedium="Print"><Volume>109</Volume><Issue>4</Issue><PubDate><Year>2001</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Human genetics</Title><ISOAbbreviation>Hum Genet</ISOAbbreviation></Journal><ArticleTitle>A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.</ArticleTitle><Pagination><MedlinePgn>429-39</MedlinePgn></Pagination><Abstract><AbstractText>The thioredoxin/glutaredoxin family consists of small heat-stable proteins that have a highly conserved CXXC active site and that participate in the regulation of many redox reactions. We have searched the human genome sequence to find putative pseudogenes (non-functional copies of protein-coding genes) for all known members of this family. This survey has resulted in the identification of seven processed pseudogenes for human Trx1 and two more for human Grx1. No evidence for the presence of processed pseudogenes has been found for the remaining members of this family. In addition, we have been unable to detect any non-processed pseudogenes derived from any member of the family in the human genome. The seven thioredoxin pseudogenes can be divided into two groups: Trx1-psi2, -psi3, -psi4, -psi5 and -psi6 arose from the functional ancestor, whereas Trx1-psi1 and -psi7 originated from Trx1-psi2 and -psi6, respectively. In all cases, the pseudogenes originated after the human/rodent radiation as shown by phylogenetic analysis. This is also the case for Grx1-psi1 and Grx1-psi2, which are placed between rodent and human sequences in the phylogenetic tree. Our study provides a molecular record of the recent evolution of these two genes in the hominid lineage.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Spyrou</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institute, 141 57 Huddinge, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Padilla</LastName><ForeName>C A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Holmgren</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Miranda-Vizuete</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Hum Genet</MedlineTA><NlmUniqueID>7613873</NlmUniqueID><ISSNLinking>0340-6717</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>52500-60-4</RegistryNumber><NameOfSubstance UI="D013879">Thioredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.-</RegistryNumber><NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002877" MajorTopicYN="N">Chromosomes, Human</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015894" MajorTopicYN="N">Genome, Human</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010088" MajorTopicYN="Y">Oxidoreductases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020161" MajorTopicYN="N">Physical Chromosome Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011544" MajorTopicYN="N">Pseudogenes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012689" MajorTopicYN="N">Sequence Homology, Nucleic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013879" MajorTopicYN="N">Thioredoxins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2001</Year><Month>05</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2001</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>11</Month><Day>10</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>1</Month><Day>5</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>11</Month><Day>10</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11702225</ArticleId><ArticleId IdType="doi">10.1007/s004390100597</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Holmgren, A" sort="Holmgren, A" uniqKey="Holmgren A" first="A" last="Holmgren">A. Holmgren</name><name sortKey="Miranda Vizuete, A" sort="Miranda Vizuete, A" uniqKey="Miranda Vizuete A" first="A" last="Miranda-Vizuete">A. Miranda-Vizuete</name><name sortKey="Padilla, C A" sort="Padilla, C A" uniqKey="Padilla C" first="C A" last="Padilla">C A Padilla</name><name sortKey="Wilson, W" sort="Wilson, W" uniqKey="Wilson W" first="W" last="Wilson">W. Wilson</name></noCountry><country name="Suède"><noRegion><name sortKey="Spyrou, G" sort="Spyrou, G" uniqKey="Spyrou G" first="G" last="Spyrou">G. Spyrou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/GlutaredoxinV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001042 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001042 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= GlutaredoxinV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:11702225
|texte= A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:11702225" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GlutaredoxinV1
| This area was generated with Dilib version V0.6.37. |  |